Detergent removal chromatography sorbents, SDR HyperD™

Supplier: Pall Laboratory
555-0008EA 2290 GBP
PALL20033-015 PALL20033-031 PALL20033-023
Detergent removal chromatography sorbents, SDR HyperD™
Chromatography resin for detergent removal. SDR HyperD™ is a composite sorbent that combines a silica bead moiety filled with a 3D cross-linked hydrophobic polymer. The SDR HyperD™ sorbent structure has been engineered for optimal solvent/detergent retention. Due to the degree of 3D polymer cross-linking, an exclusion limit of 10 kDa means that target proteins are ‘excluded' from the sorbent, and are found unretained in the column void volume. Conversely, the high specific surface area (200 m²/g) of the porous silica translates into a high capacity for detergent and solvents. The particle size distribution (40 - 100 µm), the silica bead pore size, and the polymer have all been optimised for retention of solvents and detergents used in viral inactivation processes (i.e., Tri-n-Butyl Phosphate and Triton® X-100). SDR HyperD™ sorbent is also effective at removing detergents typically used in protein solubilisation for other applications (i.e., ASB-14, CHAPS and SDS).

  • Binds detergent and solvent used in viral inactivation processes
  • High dynamic binding capacity for many different detergents
  • High recovery of proteins (exclusion limit 10 kDa)
  • High adsorption capacity for small hydrophobic molecules
  • Stable in acidic, polar organic and oxidising solutions
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