Anti-TNR16 Mouse Monoclonal Antibody (Unconjugated) [clone: 8J2]

Supplier: Biosensis
BSENM-1818-100EA 304 GBP
BSENM-1818-100
Anti-TNR16 Mouse Monoclonal Antibody (Unconjugated) [clone: 8J2]
Antibodies
NGF receptor antibody clone 8J2 was developed specifically as a replacement for clone MLR2, which is no longer available anywhere for commercial use. Antibody reactivity for clone 8J2 has been validated for human, mouse and rat extracellular domain of p75NTR. Clone 8J2 has been demonstrated to perform equivalent to or better than MLR2 antibody in all testing.

This antibody is specific for NGFR/p75NTR as demonstrated by western blotting and immunprecipitation. The antibody recognizes extracellular p75NTR under non-reducing conditions. p75NTR (CD271) was originally discovered as a low affinity nerve growth factor receptor (NGFR). Later it was found that it was the receptor for all neurotrophins, including NGF, BDNF, NT3 and NT4/5. It mediates signals of neurotrophins for neuronal survival, apoptosis, neurite outgrowth and synaptic plasticity. Recently, it has been revealed that p75NTR not only acts as the receptor for neurotrophins but also the receptor for many other pathological ligands such as prions, rabies virus and amyloid beta. p75NTR also acts as a co-receptor for NOGO which mediates inhibitory signals of myelin associated protein. p75NTR is highly expressed in a number of non-neuronal and neuronal cells including motor neurons during development and also in damaged neurons. Recent research proposes the extracellular domain of p75NTR as a biomarker for monitoring the progression of motor neuron disease (MND), also known as Amyotrophic Lateral Sclerosis (ALS) or Lou Gehrig's Disease. SUBUNIT: Homodimer; disulfide-linked. Interacts with p75NTR-associated cell death executor. Interacts with NGFRAP1/BEX3.

Type: Primary
Antigen: TNR16
Clonality: Monoclonal
Clone: 8J2
Conjugation: Unconjugated
Epitope: Extracellular
Host: Mouse
Isotype: IgG2a
Reactivity: Human, mouse, rat
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