MG-132 is a potent, cell permeable and selective proteasome inhibitor (Ki = 4 nM).1 It inhibits NF-κB activation by preventing IκB degradation (IC50 = 3 μM). The peptide blocks degradation of short-lived proteins, which in turn induces HSP and ER chaperone expression, leading to thermotolerance (1 μM MG-132, 2 h.). It also stimulates neurite outgrowth in PC12 cells (20 nM optimal). The peptide has also been reported to increase the survival rate of mesenchymal stem cells following their transplantation. IC50’s for inhibition of Suc-LLVY-AMC and Z-LLL-AMC cleaving activities of proteasome were 0,85 and 0,1 μM respectively. The ubiquitin-proteasome system (UPS) and autophagy serve as two complementary, reciprocally regulated protein degradation systems, thus blockade of UPS by MG-132 activates autophagy.
- Key inhibitor for use in proteasome research.
White solid.
Soluble in DMSO (25 mg/ml) or 100% ethanol (25 mg/ml).
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- Protein synonyms:Z-LLL-CHO
- Protein/peptide name:MG-132
Product Information
- Catalog #Supplier #PkAvailabilityPrice
- ENZOBMLPI1020005BMLPI10200055 mg1 * 5 mg£71.10: BMLPI1020005: ENZOBMLPI1020005
- : BMLPI1020025: ENZOBMLPI1020025