About this item
Nuclear factor kappa-B (NFk) B) functions as a sequence specific transcriptional activator that binds to the intronic enhancer of kappa light chain gene in B lymphocytes. NF-kB is a heterodimer consisting of a 50 kDa DNA binding subunit (p50) and a 65 kDa transactivation subunit (p65/RelA) (ref. 3), both of which exhibit sequence homology to the protooncogene c-Rel. p50 has an isoform called p49/p52, and both proteins derive from the amino-terminal of precursor protein p105 and p100, respectively. The p50/p65 heterodimer remains in inactive form in the cytosol as a complex with its inhibitor, IkB. Upon stimulation of cells by a variety of stimuli, including lipopolysaccharide (LPS), pro-inflammatory cytokines like interleukin-1 and tumor necrosis factor, and viral infection, IkB becomes phosphorylated and degraded by the proteosome. The active NF-kB heterodimer translocates into the nucleus and induces gene expression.
- For Western Blot
Recognizes human, mouse, rat, bovine, dog, guinea pig, monkey, pig and rabbit NF-kappaB p65. Detects a band of ~65kDa by Western blot.
Type: Primary
Antigen: NF-KAPPAB P65
Clonality: Polyclonal
Clone:
Conjugation:
Epitope:
Host: Rabbit
Isotype:
Reactivity: Human
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Specifications
- Catalog No:
- ENZOADIKASTF110F
- ENZOADIKASTF110D
- Antigen symbol:
- NF-kappa B P65
- NF-kappa B P65
- Antibody type:
- Primary
- Primary
- Clonality:
- Polyclonal
- Polyclonal
- Reactivity:
- Human
- Human
- Host:
- Rabbit
- Rabbit
- Western blot:
- Yes
- Yes
- Form:
- Liquid. In PBS, pH 7,2, containing 0,09% sodium azide.
- Liquid. In PBS, pH 7,2, containing 0,09% sodium azide.
- Purification:
- Protein A affinity purified
- Protein A affinity purified
Specifications
Product Information
- Catalog #Supplier #PkAvailabilityPrice
- ENZOADIKASTF110DADIKASTF110D50 µG1 * 50 µG£220.00Specifications:
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Specifications
Antigen symbolNF-kappa B P65Environmentally PreferableAntibody typePrimaryClonalityPolyclonalReactivityHumanHostRabbitIsotypeWestern blotYesFormLiquid. In PBS, pH 7,2, containing 0,09% sodium azide.PurificationProtein A affinity purified - ENZOADIKASTF110FADIKASTF110F200 µG1 * 200 µG£486.00Specifications:
More
Specifications
Antigen symbolNF-kappa B P65Environmentally PreferableAntibody typePrimaryClonalityPolyclonalReactivityHumanHostRabbitIsotypeWestern blotYesFormLiquid. In PBS, pH 7,2, containing 0,09% sodium azide.PurificationProtein A affinity purified