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- Antibody type:Primary
- Antigen name:c-Jun N-terminal kinase 1, c-Jun N-terminal kinase 2, c-Jun N-terminal kinase 3
- Antigen symbol:JNK1 / JNK2 / JNK3
- Clonality:Polyclonal
- Conjugation:Cy3®
- Host:Rabbit
- ImmunoChemistry:Yes
- Isotype:IgG
- Reactivity:Human,Rat,Mouse
- Cross adsorption:No
- Form:liquid
- Gene ID:26419,26420,26414
- Antigen synonyms:stress-activated protein kinase 1c|MAPK10|JNK3|JNK3A|stress-activated protein kinase 1|JNK1A2|SAPK1a|Stress-activated protein kinase 1b|SAPK1|MAP kinase 10|MAP kinase p49 3F12|Mitogen-activated protein kinase 9|JNK-55|mitogen-activated protein kinase 8 isoform JNK1 alpha1|PRKM9|c-Jun N-terminal kinase 2|PRKM8|JNK-46|SAPK1A|Stress-activated protein kinase JNK3|JNK|MAP kinase 9|SAPK1B|MAPK9|JNK2|MAP kinase 8|JNK1|SAPK1c|SAPK1b|PRKM10|c-Jun N-terminal kinase 1|JUN N-terminal kinase|Stress-activated protein kinase JNK2|MAPK8|MAPK 10|Stress-activated protein kinase 1a|JNK21B1/2|mitogen-activated protein kinase 8 isoform JNK1 beta2|Mitogen-activated protein kinase 10|MAPK 9
- Storage buffer:Aqueous buffered solution containing 100ug/ml BSA, 50% glycerol and 0.09% sodium azide. Store at 4°C for 12 months.
- Storage temperature:Store at 4°C for 12 months
- Concentration:1 μg/μl
- Shipping temperature:4°C
- Immunogen:160-210/384
- Purification:Purified by Protein A
- Pk:100 µl
Serine/threonine-protein kinase involved in various processes such as neuronal proliferation, differentiation, migration and programmed cell death. Extracellular stimuli such as proinflammatory cytokines or physical stress stimulate the stress-activated protein kinase/c-Jun N-terminal kinase (SAP/JNK) signaling pathway. In this cascade, two dual specificity kinases MAP2K4/MKK4 and MAP2K7/MKK7 phosphorylate and activate MAPK1/JNK3. In turn, MAPK1/JNK3 phosphorylates a number of transcription factors, primarily components of AP-1 such as JUN and ATF2 and thus regulates AP-1 transcriptional activity. Plays regulatory roles in the signaling pathways during neuronal apoptosis. Phosphorylates the neuronal microtubule regulator STMN2. Acts in the regulation of the beta-amyloid precursor protein/APP signaling during neuronal differentiation by phosphorylating APP. Participates also in neurite growth in spiral ganglion neurons.
Recommended Dilutions: IF(IHC-P): 1:50-200
Type: Primary
Antigen: JNK1 / JNK2 / JNK3
Clonality: Polyclonal
Clone:
Conjugation: Cy3®
Epitope:
Host: Rabbit
Isotype: IgG
Reactivity: Human, Mouse, Rat