Anti-BDNF Mouse Monoclonal Antibody [clone: 4C8]

Supplier: Biosensis
BSENM-1744-50EA 235 GBP
BSENM-1744-50
Anti-BDNF Mouse Monoclonal Antibody [clone: 4C8]
Antibodies
BDNF belongs to the neurotrophin family and promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it. It is a major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including long-term potentiation (LTP), long-term depression (LTD), certain forms of short-term synaptic plasticity, as well as homeostatic regulation of intrinsic neuronal excitability. The alterations in BDNF expression induced by various kinds of brain insult including stress, ischemia, seizure activity and hypoglycemia, may contribute to some pathologies such as depression, epilepsy, Alzheimer's, and Parkinson's disease. Microglia release BDNF that may contribute to neuroinflammation and neuropathic pain. SUBUNIT: Monomers and homodimers. Binds to NTRK2/TRKB. SUBCELLULAR LOCATION: Secreted protein. POst translation modification: Converted into mature BDNF by plasmin (PLG). SIMILARITY: Belongs to the NGF-beta family.

ELISA (50 to 100 ng/mL), WB (denaturing and reducing, 0.2 to 2 µg/mL), IF (1 to 4 µg/mL, 4% formaldehyde fixation), Flow Cytometry (~2 µg per 106 cells, methanol fixation), IHC (2 to 5 µg/mL; antigen retrieval procedure with citrate buffer, pH 6, 5 minutes at 100°C is required). Biosensis recommends optimal dilutions/concentrations should be determined by the end user.

Type: Primary
Antigen: BDNF
Clonality: Monoclonal
Clone: 4C8
Conjugation: Unconjugated
Epitope: Recombinant human mature BDNF expressed in E.coli
Host: Mouse
Isotype:
Reactivity: Human;Mouse;Rat;Guinea Pig
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