This antibody recognizes a protein of 25-26 kDa, identified as the bcl-2 α oncoprotein. It shows no cross-reaction with Bcl-x or Bax protein. Expression of bcl-2 α oncoprotein inhibits the programmed cell death (apoptosis). In most follicular lymphomas, neoplastic germinal centers express high levels of bcl-2 α protein, whereas the normal or hyperplastic germinal centers are negative. Consequently, this antibody is valuable when distinguishing between reactive and neoplastic follicular proliferation in lymph node biopsies. It may also be used in distinguishing between those follicular lymphomas that express bcl-2 protein and the small number in which the neoplastic cells are bcl-2 negative.
Type: Primary
Antigen: BCL2
Clonality: Monoclonal
Clone: BCL2/782
Conjugation: Biotin
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
- Catalog No:
- BNCB0782-100
- BNCB0782-500
- Antigen symbol:
- BCL2
- BCL2
- Antigen name:
- bcl-2
- bcl-2
- Antigen synonyms:
- Apoptosis regulator Bcl-2|B-cell CLL/lymphoma-2
- Apoptosis regulator Bcl-2|B-cell CLL/lymphoma-2
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- Biotin
- Biotin
- Clone:
- Clone BCL2/782
- Clone BCL2/782
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 150749
- 150749
- Isotype:
- IgG1 kappa
- IgG1 kappa
- Western blot:
- Yes
- Yes
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
- SizePk
- : BNCB0782-100: BTIUBNCB0782-100
Specifications
Antigen symbolBCL2Antigen namebcl-2Environmentally PreferableAntigen synonymsApoptosis regulator Bcl-2|B-cell CLL/lymphoma-2Antibody typePrimaryClonalityMonoclonalConjugationBiotinCloneClone BCL2/782ReactivityHumanHostMouseGene ID150749IsotypeIgG1 kappaWestern blotYesImmunoChemistryYesImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide - : BNCB0782-500: BTIUBNCB0782-500
Specifications
Antigen symbolBCL2Antigen namebcl-2Environmentally PreferableAntigen synonymsApoptosis regulator Bcl-2|B-cell CLL/lymphoma-2Antibody typePrimaryClonalityMonoclonalConjugationBiotinCloneClone BCL2/782ReactivityHumanHostMouseGene ID150749IsotypeIgG1 kappaWestern blotYesImmunoChemistryYesImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide