Recognizes a protein of 104 kDa-110 kDa, characterized as major vault protein (MVP). Vaults are large ribonucleoprotein particles (RNPs) present in all eukaryotic cells. They have a complex morphology, including several small molecules of RNA, but a single protein species. The MVP accounts for >70% of their mass. Their shape is reminiscent of the nucleopore central plug. Treatment of cells with estradiol increases the amount of MVP in nuclear extract. The hormone-dependent interaction of vaults with ER is prevented in vitro by sodium molybdate. Antibodies to estrogen, progesterone and glucocorticoid receptors are able to co-immunoprecipitate the MVP. MVP is overexpressed in many neoplastic tissues and cell lines. Expression of MVP predicts a poor response to chemotherapy.
Type: Primary
Antigen: MVP
Clonality: Monoclonal
Clone: 1032
Conjugation: CF488A
Epitope:
Host: Mouse
Isotype: IgG1 kappa
Reactivity: Human
- Catalog No:
- BNC880225-500
- BNC880225-100
- Antigen symbol:
- MVP
- MVP
- Antigen name:
- Major Vault Protein
- Major Vault Protein
- Antigen synonyms:
- MVP|VAULT1|Major Vault Protein|Lung resistance-related protein (LRP)
- MVP|VAULT1|Major Vault Protein|Lung resistance-related protein (LRP)
- Antibody type:
- Primary
- Primary
- Clonality:
- Monoclonal
- Monoclonal
- Conjugation:
- CF® 488A
- CF® 488A
- Clone:
- Clone 1032
- Clone 1032
- Reactivity:
- Human
- Human
- Host:
- Mouse
- Mouse
- Gene ID:
- 632177
- 632177
- Isotype:
- IgG1 kappa
- IgG1 kappa
- ImmunoChemistry:
- Yes
- Yes
- ImmunoFluorescence:
- Yes
- Yes
- Concentration:
- 0,1 mg/ml
- 0,1 mg/ml
- Storage buffer:
- PBS/0,1% BSA/0,05% azide
- PBS/0,1% BSA/0,05% azide
Product Information
- Catalog #Supplier #SizePkAvailabilityPrice
- BNC880225-500BNC880225-500500 μL500 µl1 * 500 µl£538.00: BNC880225-500: BTIUBNC880225-500
Specifications
Antigen symbolMVPAntigen nameMajor Vault ProteinEnvironmentally PreferableAntigen synonymsMVP|VAULT1|Major Vault Protein|Lung resistance-related protein (LRP)Antibody typePrimaryClonalityMonoclonalConjugationCF® 488ACloneClone 1032ReactivityHumanHostMouseGene ID632177IsotypeIgG1 kappaImmunoChemistryYesImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide - : BNC880225-100: BTIUBNC880225-100
Specifications
Antigen symbolMVPAntigen nameMajor Vault ProteinEnvironmentally PreferableAntigen synonymsMVP|VAULT1|Major Vault Protein|Lung resistance-related protein (LRP)Antibody typePrimaryClonalityMonoclonalConjugationCF® 488ACloneClone 1032ReactivityHumanHostMouseGene ID632177IsotypeIgG1 kappaImmunoChemistryYesImmunoFluorescenceYesConcentration0,1 mg/mlStorage bufferPBS/0,1% BSA/0,05% azide