Bafilamycin A1 ≥95% (by HPLC, TLC)
Supplier: ENZO LIFE SCIENCES
Macrolide antibiotic that acts as a potent and selective inhibitor of vacuolar-type H+-ATPase (V-type) (IC50=004 - 0.4 nmol/mg). Valuable tool for distinguishing among different types of ATPases. Inhibitor of endosomal acidification. Blocks lysosomal cholesterol trafficking in macrophages. Blocks pH regulation in brain cells.
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Bafilamycin A1
Supplier: Thermo Fisher Scientific
Bafilomycin A1 is a specific potent inhibitor of vacuolar ATPases. Used as an antibacterial, antifungal, antineoplastic, an immunosuppressive and also prevents maturation of autophagic vacuoles by inhibiting fusion between autophagosomes and lysosomes and is a macrolide antibiotic and potent and selective inhibitor of vacuolar-type H+ ATPase (V-ATPase).