Supplier: Thermo Fisher Scientific

7-Ethyl-10-hydroxycamptothecin 98%

Supplier: Cayman Chemical

SN-38 is the active metabolite of irinotecan, a derivative of the alkaloid camptothecin and acts as a potent inhibitor of DNA topoisomerase I. SN-38 is a more potent topopisomerase I inhibitor and more cytotoxic to HT-29 colon cancer cells (IC₅₀ = 8.8 nM) compared to irinotecan (IC₅₀ >100 nM).